Which route(s) can Procainamide be administered?

Procainamide can be administered through multiple routes, specifically intravenously (IV), intraosseously (IO), and orally (PO), making the third option the correct choice.

The IV route allows for rapid administration and quicker onset of action, which is often crucial in emergency settings where immediate control of cardiac arrhythmias is necessary. The IO route is also utilized in emergencies when IV access may be difficult or impossible to establish, providing an alternative for administering the drug directly into the bone marrow, where it enters the systemic circulation quickly. Additionally, the oral route provides a convenient option for chronic management of certain cardiac conditions, allowing patients to take the medication at home as prescribed.

The availability of Procainamide in these various administration routes enhances its versatility as a therapeutic agent in managing cardiac arrhythmias, aligning with treatment protocols in both acute and chronic settings.