Which of the following is an adverse effect of Diltiazem?

Diltiazem, a calcium channel blocker, is often used in the treatment of hypertension and certain types of angina. One of the common adverse effects associated with the use of Diltiazem is edema, particularly peripheral edema. This occurs because calcium channel blockers can cause vasodilation, which may lead to fluid accumulation in the tissues and result in swelling.

While other side effects such as nausea, rash, and insomnia can also occur with Diltiazem, they are not as closely associated or prominent as edema. Edema is especially noteworthy as it can be a source of discomfort and may require additional management to address fluid retention in patients undergoing treatment with this medication. Understanding this side effect is crucial for healthcare providers to monitor and manage patients effectively.