Which of the following is a common gastrointestinal adverse effect of Acetylsalicylic Acid?

Acetylsalicylic Acid, commonly known as aspirin, is a non-steroidal anti-inflammatory drug (NSAID) that is widely used for its analgesic, anti-inflammatory, and antipyretic properties. While it is effective for pain relief and inflammation, it can also cause gastrointestinal disturbances. Nausea is a well-known gastrointestinal adverse effect of aspirin, often arising due to its irritating effects on the gastric mucosa.

When aspirin is ingested, it can lead to an increase in gastric acid secretion, which irritates the stomach lining, potentially causing feelings of nausea. This effect can be exacerbated by factors such as high doses or chronic usage. Additionally, the risk of gastrointestinal side effects is one reason why healthcare providers may recommend taking aspirin with food or using protective medications for individuals who require long-term use.

Understanding the mechanisms behind these adverse effects is crucial, as they highlight the importance of monitoring patients on aspirin therapy for signs of gastrointestinal discomfort and implement strategies to minimize these risks.