Which of the following is an adverse effect of Lidocaine?

Lidocaine, which is commonly used as a local anesthetic and antiarrhythmic agent, can indeed lead to seizures as a significant adverse effect. This occurs primarily due to its ability to affect the central nervous system, especially when used in high doses or in individuals with compromised liver function, which can interfere with the drug's metabolism.

Seizures may manifest as generalized tonic-clonic convulsions, and this response to lidocaine is related to its action on sodium channels in neuronal cells, which can lead to an excitatory effect if plasma levels become too high. Therefore, while other side effects like headache, nausea, and bradycardia can also occur, seizures are particularly concerning and highlight the drug's potential neurotoxic effects when misused or overdosed. Understanding these adverse effects is crucial for safe administration and monitoring of patients receiving lidocaine.