When using Procainamide, what must be considered if co-administering with Amiodarone?

When administering Procainamide alongside Amiodarone, it is important to consider that Amiodarone has the potential to decrease the elimination of Procainamide. Amiodarone can affect liver metabolism and kidney excretion, leading to increased levels of Procainamide in the system. This interaction necessitates close monitoring of procainamide levels to avoid the risk of toxicity, as elevated levels can lead to adverse effects such as hypotension and arrhythmias.

In contrast, the other options do not accurately reflect the pharmacokinetic relationship between these two drugs. Amiodarone does not enhance Procainamide elimination; instead, it slows it down. Furthermore, stating that both drugs do not interact ignores the significant implications of their pharmacological effects when co-administered, especially regarding the metabolism and clearance of Procainamide. Lastly, while Amiodarone can influence heart rate due to its anti-arrhythmic properties, the specific question focuses on the interaction related to the elimination of Procainamide.