What should be done after administering the first dose of Adenosine?

After administering the first dose of Adenosine, following with a 20 mL saline flush is recommended to help ensure that the medication is delivered effectively into the bloodstream and to reduce the chance of the drug being metabolized before it reaches its target. Adenosine has a very short half-life and is rapidly cleared from the circulation; flushing with a larger volume of saline helps to push the medication through the intravenous line and into systemic circulation more effectively.

This practice maximizes the likelihood of achieving the desired therapeutic effect, which is critical given that Adenosine is used for the quick termination of certain types of supraventricular tachycardia. The quick administration followed by flushing reinforces the effectiveness of the treatment and aids in the rapid response needed in these acute settings.