What effect does morphine have on histamine release?

Morphine is known to cause the release of histamine from mast cells. This is an important pharmacological effect because histamine release can lead to various physiological responses, including vasodilation and potential hypotension. The mechanism behind this involves morphine interacting with the opioid receptors, which can stimulate mast cells to degranulate and subsequently release histamine.

Understanding this effect is crucial for healthcare providers, particularly when administering morphine, as they may need to monitor for signs of allergic reactions or histamine-related side effects, such as itching, flushing, or changes in blood pressure. Hence, knowing that morphine causes histamine release helps in preparing for and managing these potential complications effectively.