What clinical effect does Diltiazem have on the AV node?

Diltiazem is a calcium channel blocker that primarily affects the heart and vascular system. Its clinical effect on the atrioventricular (AV) node is significant in managing certain cardiac conditions, such as atrial fibrillation and atrial flutter.

When administered, Diltiazem inhibits calcium influx during depolarization in cardiac tissue, which leads to a decrease in the conduction speed through the AV node. This is particularly useful for controlling the ventricular response in rapid atrial arrhythmias, allowing for more controlled heart rates. By prolonging conduction time in the AV node, Diltiazem helps reduce the heart rate and stabilize arrhythmias.

Thus, the action of prolonging conduction time in the AV node is critical in managing arrhythmias and ensuring the heart maintains an effective rhythm, making this the correct choice in regard to Diltiazem's effects on the AV node.