How is the dosage of Norepinephrine titrated?

The correct approach to titrating the dosage of Norepinephrine is focused on maintaining an adequate blood pressure. This medication is primarily used in critical care settings to manage severe hypotension, typically seen in conditions such as septic shock. The goal is to sustain the systolic blood pressure (SBP) above 90 mmHg or mean arterial pressure (MAP) above 65 mmHg, which are indicative of adequate perfusion to vital organs.

Maintaining these blood pressure levels is crucial for ensuring that the body's tissues receive sufficient oxygen and nutrients, which helps prevent organ failure. By titrating the Norepinephrine dose based on these thresholds, healthcare providers can effectively manage a patient's hemodynamic status while minimizing the risk of complications related to over-treatment, such as excessive vasoconstriction and subsequent tissue ischemia.

Other options provided do not align with the primary clinical use of Norepinephrine. For instance, while heart rate can be an important parameter in some scenarios, it is not the primary target for Norepinephrine titration. Similarly, decreasing oxygen demand or stabilizing glucose levels are not relevant to the primary purpose of Norepinephrine, which centers around enhancing blood pressure and ensuring adequate organ perfusion.